PREDNISOLONE -
Noun: A powerful corticosteroid drug which reduces inflammation that the ALG treatment may cause, by blocking the action of chemicals called " prostaglandins " that are responsible for triggering the inflammatory response.

Prednisolone may also act on the brain to produce a heightened sense of well-being and happiness, but its use suppresses the production of the body's own corticosteroid hormones which are produced by the adrenal glands. For this reason, treatment that lasts for more than a few weeks must be withdrawn gradually to give your body a chance to adjust and start producing it's own. If the drug is stopped abruptly, the lack of corticosteroid hormones may lead to a sudden emotional collapse until levels rise naturally. The drug may also cause depression or other mood swings when taken.

Use of this drug in standard doses eases the side effects of the ALG treatment but they do not have any effect on the aplastic anaemia or myelodysplasia .

Prednisolone can cause fluid retention, indigestion, acne, and more rarely, eye problems, fragile bones and diabetes if taken in large doses over a long period. Dosages are usually tailored to minimize these effects.

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