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Aplastic Anaemia and Myelodysplasia Glossary > Glossary > Cyclophosphamide

CYCLOPHOSPHAMIDE -
Noun: A drug used to treat cancers and to suppress the rejection of transplanted tissue. It basically kills off all the white cells . It is the drug of choice for those having a Bone Marrow Transplant.

Cyclophosphamide commonly causes nausea, vomiting and hair loss and can affect the heart, lungs and liver. It can also cause severe bladder damage in susceptible people because it produces a toxic substance called acrolein (a colourless liquid with an irritating odour and used in chemical warfare as a tear gas). Another drug may be given before and after each dose of cyclophosphamide to reduce its toxicity. Inform your doctor if you find it painful to pass urine while you are on this drug. It can also lead to abnormal bleeding due to lowered blood cells, and increased risk of infection and reduced fertility in men. Drink lots of water while taking this drug. This will usually prevent it from causing bladder irritation.


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