CHRONIC -
Adjective: A term describing a disorder or set of symptoms that has persisted for a long time. With GVHD the time specified is over 100 days. Chronic disorders are usually contrasted with acute ones (of sudden onset and short in duration). In addition to the difference in duration between the two, the term acute suggests the presence of symptoms such as high fever, severe pain, or breathlessness, with a rapid change in the patient's condition from one day to the next. By contrast, a person with a chronic infection shows little change in symptoms from day to day and may be able, with some difficulty, to carry out his or her daily activities.

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