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Aplastic Anaemia and Myelodysplasia Glossary > Glossary > Methotrexate

METHOTREXATE -
Noun: An anticancer drug used in treating certain forms of leukaemia . As with most anticancer drugs, methotrexate affects both healthy and cancerous cells, so that its usefulness is limited by its adverse effects and toxicity. It has been reported to reduce the IQ of children. It may also reduce fertility by depressing sperm and egg development. It has been used to reduce the symptoms of acute GVHD . It commonly causes nausea, vomiting, diarrhoea, dry cough/chest pain and mouth ulcers. If you notice any of these symptoms or jaundice , mood changes, confusion, sore throat, fever or a rash, contact your doctor. It may also cause anaemia, increased susceptibility to infection and abnormal bleeding due to killing off blood cells.


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