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BONE MARROW TREPHINE - Noun: 1. An instrument used for cutting out a piece of bone. In all patients with aplastic anaemia or myelodysplasia , a sample of bone, and bone marrow will be required. This involves obtaining a small amount of marrow from inside the bone with a needle and a sample of the bone itself showing the structure of the bone marrow cavity (where the bone marrow grows).
2. The small piece of bone is also called a bone marrow trephine. The samples used are usually obtained from the back of the hip bone. The procedure causes some discomfort but does not take very long. The procedure is usually carried out with sedation as well as local anaesthetic. It may be necessary to sample more than one site in AA or MDS patients to confirm that there is no other bone marrow disease present.
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